Results
| PMID | 18555226 |
| Gene Name | MUC16 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 760 |
| Population details | 760 (231 patients with endometriosis, 145 patients with benign ovarian tumors, and 384 healthy controls ) |
| Sex | Female |
| Associated genes | CA-125 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2008 Dec;90(6):2073-9. doi: 10.1016/j.fertnstert.2008.03.061. Epub Cho, SiHyun| Cho, Hanbyoul| Nam, Anna| Kim, Hye Yeon| Choi, Young Sik| Park, Ki Hyun| Cho, Dong Je| Lee, Byung Seok Department of Obstetrics and Gynecology, Yongdong Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea. OBJECTIVE: To investigate the clinical value of differential white blood cell counts and neutrophil-to-lymphocyte ratio (NLR), by themselves or as adjunct to CA-125, in the diagnosis of endometriosis. DESIGN: Retrospective study. SETTING: University Medical Center. PATIENT(S): Two hundred thirty-one patients with endometriosis, 145 patients with benign ovarian tumors, and 384 healthy controls participated in this study. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Sensitivities and specificities of differential white blood cell (WBC) counts, NLR, serum CA-125, and the combined marker (NLR and serum CA-125) were evaluated by receiver-operating characteristic (ROC) analysis. RESULT(S): The mean NLR and the combined marker in patients with endometriosis were significantly higher than those in patients without endometriosis. The NLR was able to discriminate patients with endometriosis from those with benign ovarian tumors and from healthy controls, and 25 of the 38 endometriosis patients (65.8%) with minimal-to-mild disease exceeded the cutoff value. The combined marker had a sensitivity of 69.3% and specificity of 83.9% with a cutoff value of 55.7, showing 13.5% increase in sensitivity but 8.9% decrease in specificity when compared with serum CA-125 at a cutoff level of 35 IU/mL. The elevated combined marker detected 16 patients with endometriosis (42.1%) with minimal-to-mild disease, whereas only 10 patients (26.3%) had their serum CA-125 levels at more than 35 IU/mL. CONCLUSION(S): Measurement of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis. Mesh Terms: Adult| CA-125 Antigen/*blood| Endometriosis/blood/*diagnosis/immunology| Female| Humans| *Leukocyte Count| *Lymphocyte Count| *Neutrophils| Predictive Value of Tests| ROC Curve| Retrospective Studies| Sensitivity and Specificity|DA 2008/12/24 0 |
|